Endocrine Abstracts

Background: Therapeutic activation of thermogenic brown adipose tissue (BAT) is a potential strategy to prevent obesity and metabolic disease in humans. However, it is now recognised that rodent studies examining BAT physiology are carried out at sub-thermoneutral temperatures (e.g. ~20°C), and are not translationally relevant to humans as BAT is ‘hyperactive’. Therefore, the aim of this study was to determine the effect of common regulators of BAT metabolism wh...

Brown adipose tissue (BAT) is present in small quantities in human adults (~100 g) and can have a significant influence on metabolism. This effect is mediated by rapid activation of the BAT specific uncoupling protein 1 (UCP1), following stimulation of β-adrenergic receptor (AR) by the sympathetic nervous system. AR agonists stimulate rodent BAT, but have so far provided inconsistent findings in humans when administered orally (Vosselman et al. 2012). Rapid activ...

The identification and characterisation of unique gene profiles expressed in specific adipose tissue depots around the body could provide novel insights on fat development.We report a comprehensive analysis of transcriptome from the five major (epicardial, pericardial, perirenal, sternal and omental) adipose depots from one week old sheep. This study also provides an integrated view of the preservation and differences between mitochondrial gene co-expres...